Hepatitis G Virus Infection: A Work in Progress

Editorials1 November 1996Hepatitis G Virus Infection: A Work in ProgressAdrian M. Di Bisceglie, MDAdrian M. Di Bisceglie, MDSt. Louis University School of Medicine, St. Louis, MO 63104.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-9-199611010-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Before the hepatitis C virus (HCV) was identified in 1989, there was speculation about the existence of more than one blood-borne viral agent causing non-A, non-B hepatitis [1]. This speculation has continued and is supported by evidence of several unexplained hepatitis-associated syndromes, including cryptogenic hepatitis and cirrhosis, fulminant hepatic failure of unknown cause, and aplastic anemia. None of these syndromes is clearly linked to any of the known hepatitis viruses. Thus, great interest was generated when separate groups of investigators announced the discovery of new hepatitis viruses in 1995 [2-4]. Both discoveries were made by industry-based investigators who collaborated with ...References1. Alter HJ. Transfusion-associated non-A, non-B hepatitis: the first decade. In: Zuckerman AJ, ed. Viral Hepatitis and Liver Disease. New York: Liss; 1988:537-42. Google Scholar2. Simons JN, Pilot-Matias TJ, Leary TP, Sawson GJ, Desai SM, Schlauder GG, et al. Identification of two flavivirus-like genomes in the GB hepatitis agent. Proc Natl Acad Sci U S A. 1995; 92:3401-5. Google Scholar3. Schlauder GG, Dawson GJ, Simons JN, Pilot-Matias TJ, Gutierrez RA, Heynen CA, et al. Molecular and serologic analysis in the transmission of the GB hepatitis agents. J Med Virol. 1995; 46:81-90. Google Scholar4. Linnen J, Wages J Jr, Zhang-Keck ZY, Fry KE, Krawczynski KZ, Alter H, et al. Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent. Science. 1996; 271:505-9. Google Scholar5. Deinhardt F, Holmes AW, Capps RB, Popper H. Studies on the transmission of human viral hepatitis to marmoset monkeys. I. Transmission of disease, serial passages, and description of liver lesion. J Exp Med. 1967; 125:673-87. Google Scholar6. Alter HJ. The cloning and clinical implications of HGV and HGBV-C [Editorial]. N Engl J Med. 1996; 334:1536-7. Google Scholar7. Masuko K, Mitsui T, Iwano K, Yamazaki C, Okuda K, Meguro T, et al. Infection with hepatitis GB virus C in patients on maintenance hemodialysis. N Engl J Med. 1996; 334:1485-90. Google Scholar8. Tanaka E, Alter HJ, Nakatsuji Y, Shih JW, Kim JP, Matsumoto A, et al. Effect of hepatitis G virus infection on chronic hepatitis C. Ann Intern Med. 1996; 125:740-3. Google Scholar Author, Article, and Disclosure InformationAuthors: Adrian M. Di Bisceglie, MDAffiliations: St. Louis University School of Medicine, St. Louis, MO 63104.Corresponding Author: Adrian M. Di Bisceglie, MD, Department of Internal Medicine, St. Louis University School of Medicine, 1402 South Grand Boulevard, St. Louis, MO 63104. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEffect of Hepatitis G Virus Infection on Chronic Hepatitis C Eiji Tanaka , Harvey J. Alter , Yoshiyuki Nakatsuji , J. Wai-Kuo Shih , Jungsuh P. 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