Two patients and a healthy blood donor were found to be Lan negative and to have anti-Lan in their sera. These are the first three examples of the Lan-negative phenotype to be described in Japanese. The families of two of the propositi were studied: the parents of both were first cousins and one of the propositi had a Lan-negative sibling. No Lan-negative examples were found in 15,000 Japanese donors screened with anti-Lan.
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Okubo et al. (1984) studied this question.
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