We have selected from a mixture of random polynucleotides an RNA that is able to replicate in the presence of the DNA-dependent RNA polymerase of Escherichia coli, provided the medium contains Mn(2+) and ITP, in addition to ATP, CTP, and UTP. The RNA consists of a chain of about 125 (+/-25) nucleotides and appears to have a defined, nonrepetitive sequence.
No takes yet. Share an insight, caveat, or question.
Biebricher et al. (1973) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: