Key result
Elevated left ventricular sphericity index was the most powerful predictor for rapid progression of myocardial fibrosis in patients with Fabry cardiomyopathy (OR 10.38).
Cohort (n=74)
No
Odds Ratio: 10.38 (95% CI 2.91–37.01)
p-value: p=<0.001
In patients with Fabry cardiomyopathy, left ventricular geometry (sphericity index) and systolic blood pressure are significant predictors of rapid progression of myocardial fibrosis.
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May warrant intensified fibrosis surveillance in high-sphericity Fabry patients; leaves open whether geometry-targeted interventions alter progression.
Krämer et al. (2015) conducted a cohort in Fabry Cardiomyopathy (n=74). Elevated left ventricular sphericity index and systolic blood pressure vs. Normal sphericity index and lower systolic blood pressure was evaluated on Rapid progression of late enhancement (myocardial fibrosis ≥0.2% per year) (OR 10.38, 95% CI 2.91-37.01, p=<0.001). Elevated left ventricular sphericity index was the most powerful predictor for rapid progression of myocardial fibrosis in patients with Fabry cardiomyopathy (OR 10.38).