Ecologically sound chemistry relies on the development of new, environmentally friendly synthetic methods in which few toxic substances are used. Copper powder was found to be a suitable initiator for the addition in Equation (a) (R1, R2 = H, alkyl, (CH2)nCOOMe). This initiator is not only cheap but also nontoxic, easily removed, and readily recyclable.
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Metzger et al. (1995) studied this question.
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