A convenient synthesis of new heterocycles such as 7,8‐dihydro‐1H‐imidazo[2,1‐i]purin‐5(4H)‐ones (2, n = 0) and 5,6‐dihydro‐1H‐imidazo[2,1‐b]purin‐9(8H)‐ones (3) was described. The syntheses of 2 and 3 were accomplished by treatment of 6‐methylthio‐7H‐purin‐2(3‐H)‐ones 7 or 2‐benzylthio‐1‐methyl‐9‐triphenylmethyl‐9H‐purin‐6(1H)‐one (15) with appropriate aminoalcohol followed by dehydrative cyclization using thionyl chloride. Compound 15 was efficiently prepared by benzylation of 6‐hydroxy‐2‐mercaptopurine (12) followed by tritylation and N‐methylation.
No takes yet. Share an insight, caveat, or question.
Shimada et al. (1993) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: