Distinctive Coordination Chemistry and Biological Relevance of Complexes With Macrocyclic Oxo Polyamines

Replacement of amine with amide groups in macrocyclic polyamines yields a novel series of oxo polyamine ligands which are the hybrids of macrocyclic polyamines and linear oligopeptides. Due to the involvement of imide anions in coordination, their ligand fields are stronger compared to those of macrocyclic counterparts. One consequence is stabilization of unusual oxidation states CuIII and NiIII.