Key result
Atomic force microscopy revealed that free APOBEC3G is primarily monomeric, whereas binding to single-stranded DNA shifts the equilibrium toward dimerization.
Atomic force microscopy reveals that APOBEC3G exists primarily as monomers in solution, but shifts toward dimerization upon binding single-stranded DNA.
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No immediate clinical implications; leaves open whether dimerization modulates APOBEC3G antiviral activity in vivo.
Shlyakhtenko et al. (2010) studied this question. Single-stranded DNA (ssDNA) binding vs. Free APOBEC3G was evaluated on APOBEC3G stoichiometry and oligomerization state. Atomic force microscopy revealed that free APOBEC3G is primarily monomeric, whereas binding to single-stranded DNA shifts the equilibrium toward dimerization.
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