Tetrahydrofurane und γ‐Lactone, VI. Optisch aktive N‐Boc‐δ‐Amino‐γ‐lactone aus Cyclooctin und Furan

Tetrahydrofurans and γ‐Lactones, VI. – Optically Active N‐Boc‐δ‐Amino‐γ‐lactones from Cyclooctyne and Furan The stereoselective synthesis of the title compounds (−)‐(2′R,8S)‐2b and (+)‐(2′S,8R)‐2b from (2′R,8R)1a and (2′S,8S)‐1a is described. The unprotected amino lactone 2c undergoes rearrangement to the γ‐hydroxy‐δ‐lactam 3a by treatment with hydrogen chloride.