Population
Pithed rats
Comparison
Varying inspired gas mixture or ventilation… vs Different blood gas states
Design
Preclinical
Authors
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Blood gas effects on alpha-adrenoceptor responses should not guide vasopressor choice; leaves open receptor selectivity in human acid-base disturbances.
Blood gases differentially affect alpha 1- and alpha 2-adrenoceptor-mediated pressor responses, indicating that their relative contribution to vascular tone may be misestimated depending on arterial blood gas levels.
Grant et al. (1985) studied this question.
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