Aminocyclodextrins as Selective Hosts with Several Binding Sites for Nucleotides

A simultaneous discrimination between 3′- and 5′-phosphates, 2′-oxy- and 2′-deoxyriboses and nucleobases of nucleotides is made possible by the use of β-cyclodextrins with ammonio substituents in the 6 position; the corresponding host–guest complex (shown schematically) forms in water in the process. NMR spectroscopic investigations show that the sugar unit is found inside the cyclodextrin cavity.