Fast atom bombardment (FAB) mass spectrometry has revealed a very useful technique in obtaining the mass spectrum of ceruletide (formerly caerulein), a decapeptide with a tyrosyl‐O‐sulphate residue, and of its desulphated analog. Molecular weight value for ceruletide is obtained only in the negative ion mode, whereas for [Tyr4] ceruletide this information is obtained both in negative and in positive ion detection. Positive ion mass spectra show more extended fragmentation which allows the complete amino acids sequence to be checked. The lability of the sulphate group has been confirmed, examining other sulphated peptides by field desorption mass spectrometry.
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Arlandini et al. (1984) studied this question.
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