Serums of dogs poisoned with carbon tetrachloride exhibited high activities of GOT I and GOT II with maxima 48 hours after administration of the toxic agent. At no time, however, did GOT II contribute to total activity more than 16%. In control serums the presence of GOT II could not be established with certainty. Disappearance rates of intravenously administered purified preparations of transaminase also were studied in dogs. Activity of GOT II decreased very much faster than that of GOT I. This difference may explain the uneven distribution of the 2 serum transaminases in carbon tetrachloride poisoning.
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Fleisher et al. (1961) studied this question.