Hydration of a Chiral Molecule: The Propylene Oxide⋅⋅⋅(Water)2 Cluster in the Gas Phase

Bridging the gap between a binary system and a solute in aqueous solution: Conformers of the ternary cluster propylene oxide (PO)⋅⋅⋅(H2O)2 were studied using rotational spectroscopy and high-level ab initio calculations. The experimental observation shows that the anti conformer is favored over the syn conformer, opposite to what was detected for PO⋅⋅⋅H2O, but in accord with what was predicted for PO in water.