Combined Surgery and Adjuvant Chemotherapy with High Dose Methotrexate and Folinic Acid Rescue (HDMTX‐CF) for Infiltrating Tumours of the Bladder

Summary— Of the 44 patients seen during the period January 1974 to March 1979 with category T3 or T4 bladder cancer, 33 were treated by partial or total cystectomy followed by adjuvant chemotherapy with high dose methotrexate and folinic acid rescue (HDMTX‐CF), with a survival rate at 2 years of 90%. Two patients were given palliative treatment with HDMTX‐CF alone; one of them is alive and disease‐free after 39 months.