Key result
Right hemisphere anterior cingulate cortex volume was positively correlated with respiratory sinus arrhythmia magnitude in combat veterans, independent of PTSD status.
Cross-Sectional (n=77)
Right anterior cingulate cortex volume is positively correlated with respiratory sinus arrhythmia magnitude in combat veterans, suggesting a structural basis for autonomic regulation independent of PTSD status.
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Hypothesis-generating for ACC-autonomic links in veterans; leaves causal direction and clinical utility open pending replication.
Existing data suggest anterior cingulate cortex (ACC) plays a role in autonomic regulation. In persons with posttraumatic stress disorder (PTSD), autonomic regulation appears impaired and smaller mean ACC volume has been reported. This study examined relationships between ACC volume and the magnitude of respiratory sinus arrhythmia (RSA) in 77 U.S. combat veterans at rest, 40 of whom met criteria for PTSD. RSA magnitude did not differ in combat survivors with and without PTSD, which contradicts studies comparing civilians with PTSD to nontraumatized controls. RSA magnitude was positively correlated with right but not left hemisphere ACC volume. This finding was statistically independent of the presence or absence of PTSD.
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Steven H. Woodward (2008) conducted a cross-sectional in Combat veterans with and without PTSD (n=77). Right hemisphere anterior cingulate cortex volume was evaluated on Correlation between anterior cingulate cortex volume and respiratory sinus arrhythmia magnitude. Right hemisphere anterior cingulate cortex volume was positively correlated with respiratory sinus arrhythmia magnitude in combat veterans, independent of PTSD status.
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