Why the study?
Does BN 50739 prevent delayed hypoperfusion and edema formation in rabbits with experimental spinal cord ischemia?
Population
Rabbits subjected to 25 minutes of spinal cord ischemia and 2 hours of reperfusion
Comparison
BN 50739 10 mg/kg i.p. given during ischemia vs Without treatment
Design
Preclinical
Follow-up
2 hours of reperfusion
Authors
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Should not change clinical practice; hypothesis-generating for PAF antagonism in experimental spinal cord ischemia.
Does BN 50739 prevent delayed hypoperfusion and edema formation in rabbits with experimental spinal cord ischemia?
In a rabbit model of spinal cord ischemia, antagonism of platelet-activating factor prevented delayed hypoperfusion and reduced edema, suggesting PAF plays a key role in early stroke manifestations.
Lindsberg et al. (1990) studied this question.
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