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October 1, 1984Antimicrobial Agents and Chemotherapy

In vitro activity of ciprofloxacin against aerobic gram-negative bacteria

Jennifer E. Rudin Carl W. Norden E. Shinners

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Abstract

For 177 gram-negative isolates, the MICs for ciprofloxacin ranged from 0.02 microgram/ml (Escherichia coli) to 0.31 microgram/ml (Pseudomonas aeruginosa). In time-kill curves, ciprofloxacin at 8 X the MIC almost completely killed 10(6) CFU of P. aeruginosa by 24 h. Ciprofloxacin at 4 X the MIC allowed bacterial regrowth by 24 h, with development of partial resistance to ciprofloxacin.

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Rudin et al. (1984) studied this question.

synapsesocial.com/papers/6a9163976587792532463ff4 https://doi.org/10.1128/aac.26.4.597

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