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A functional reassignment: BtrD, a protein encoded in the butirosin gene cluster, functions as a deacetylase rather than a nucleotidyltransferase as previously reported. BtrD was found to selectively catalyze the conversion of 2′-N-acetylparomamine to paromamine, strongly suggesting that butirosin's neosamine moiety originates from uridine diphospho(UDP)-N-acetylglucosamine (see picture).
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Truman et al. (2007) studied this question.
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