Key result
Among 28 pediatric patients with inflammatory bowel disease and carditis, 18 cases were medication-induced (predominantly by 5-aminosalicylates) and 10 were extraintestinal manifestations.
Why the study?
Extraintestinal symptoms of pediatric IBD involving the heart are relatively rare but associated with significant morbidity, requiring review to support timely diagnosis and management and identify knowledge gaps.
Myocarditis and pericarditis in pediatric IBD are rare but significant complications, most commonly induced by 5-ASA therapy, which typically resolve upon discontinuation of the offending agent.
Requires vigilance for rare cardiac EIMs/EICs in pediatric IBD; leaves open incidence, risk factors, and screening needs.
Inflammatory bowel disease (IBD) is a systemic disorder where extraintestinal symptoms may involve virtually any organ system. Of these extraintestinal symptoms, those involving the heart are relatively rare but associated with significant morbidity. We reviewed the existing literature on noninfectious myocarditis and pericarditis in the pediatric IBD population, including extraintestinal manifestations (EIMs) of IBD and extraintestinal complications (EICs) from medication. We focused on the incidence, presentation, diagnosis, treatment, and outcomes for timely diagnosis and management of these potentially deadly diseases. In addition, we aim to identify and highlight the gaps in current knowledge for future studies and investigations.
No takes yet. Share an insight, caveat, or question.
Cesa et al. (2022) conducted a review in Pediatric Inflammatory Bowel Disease (IBD) with myocarditis or pericarditis (n=28). Medications (5-ASA, Infliximab) or Extraintestinal Manifestations was evaluated on Etiology and clinical outcomes of carditis. Among 28 pediatric patients with inflammatory bowel disease and carditis, 18 cases were medication-induced (predominantly by 5-aminosalicylates) and 10 were extraintestinal manifestations.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: