Comparison the accuracy of noninvasive diagnosis fetal anemia using different algorithms

The aim of this study is to evaluate the accuracy of noninvasive diagnosis of moderate and severe fetal anemia using various diagnostic algorithms.Materials and methods. To evaluate the effectiveness of various algorithms for the noninvasive diagnosis of fetal anemia, 2 groups were formed, which included 70 pregnant women (one dichorionic twins). There were examined 71 fetuses. According to hematological tests of the fetus, the following groups were formed: “Anemia” — fetuses with moderate or severe anemia (n = 16, pregnant — 16) and “Norm” — fetuses with mild anemia or without anemia (n = 55, pregnant — 54, one dichorionic twins). Peak systolic velocity in the middle cerebral artery (PSV CMA) and fetal cardio-thoracic ratio (CTR) were measured by ultrasound. The results were analyzed by Statistica 10 program.Results. The proposed author’s diagnostic method that includes 2 parameters (PSV MCA and CTR) shows higher diagnostic accuracy (98.6% / 85.9%, p = 0.009), specificity (98.2% / 81.8%, p = 0.008) and predictive value of a positive test (94.1% / 61.5%, p = 0.03) in comparison with the method that includes only 1 parameter (PSV MSA).Conclusion. Noninvasive diagnosis of moderate and severe fetal anemia using two criteria (PSV MCA and CTR) provides higher efficiency in comparison with previous methods based only on the definition of PSV MCA.