Why the study?
Does the divalent cation ionophore A23187 alter contractile and biochemical properties in isolated perfused guinea pig and rat ventricles?
Does the divalent cation ionophore A23187 alter contractile and biochemical properties in isolated perfused guinea pig and rat ventricles?
The ionophore A23187 exerts indirect positive inotropic effects via histamine release and direct biochemical effects by increasing cGMP in ventricular myocardium.
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Animal findings on ionophore inotropy require caution before any clinical inference; leaves open mechanistic relevance in human myocardium.
Lindemann et al. (1979) studied this question.
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