Key result
Carriers of the ET-1 5665 T allele had an increased risk of coronary artery disease (OR 1.25; 95% CI 1.03-1.52; P=0.025), whereas homozygous ECE-1 -839G carriers had a decreased risk.
Why the study?
Do variants of the ET-1 and ECE-1 genes influence the risk of coronary artery disease?
Population
1000 matched pairs of angiographically confirmed coronary artery disease patients and hospital controls
Comparison
Variants of the ET-1 and ECE-1 genes vs Hospital controls without the variants
Design
Case-control
Authors
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Modest CAD risk associations should not change clinical practice; leaves open validation in larger prospective cohorts.
Case-Control (n=2,000)
Do variants of the ET-1 and ECE-1 genes influence the risk of coronary artery disease?
Odds Ratio: 1.25 (95% CI 1.03–1.52)
p-value: p=0.025
Polymorphisms in the ET-1 and ECE-1 genes appear to play only a minor role in the development of coronary artery disease.
Bühler et al. (2007) conducted a case-control in Coronary artery disease (n=2,000). ET-1 5665 T allele vs. Non-carriers was evaluated on Risk of coronary artery disease (OR 1.25, 95% CI 1.03-1.52, p=0.025). Carriers of the ET-1 5665 T allele had an increased risk of coronary artery disease (OR 1.25; 95% CI 1.03-1.52; P=0.025), whereas homozygous ECE-1 -839G carriers had a decreased risk.