Hypoplastic Anemias and Related Syndromes Caused by Drug Idiosyncrasy

Hypoplastic anemia is essentially the simultaneous occurrence of erythrocytic, granulocytic, and thrombocytic hypoplasia. These conditions may occur separately or in any combination. An absolute decrease in the lymphocytic series of cells is often associated, although they are relatively less affected as a rule. Agents that produce one of these syndromes will often produce two or more of these syndromes simultaneously in different persons or in larger doses. DIAGNOSIS Pure erythrocytic hypoplasia is characterized by normocytic anemia with a decrease in reticulocytes in the blood to few or none and a great decrease in the number of nucleated erythrocytes in the aspirated marrow. Granulocytic hypoplasia is characterized by a decrease in the absolute number of cells of the granulocytic series in the peripheral blood and also a great decrease in the number of these cells in the aspirated bone marrow. When the total number of neutrophils in the blood falls below