Sickle-cell Anaemia Complicated by Megaloblastic Anaemia of Infancy

The association between megaloblastic anaemia and various haemolytic anaemias is well documented. The most recent publications on the subject are by Chanarin et al. (1959) and Jonsson et al. (1959). The latter authors review 13 cases from the literature, and add three cases of their own. Two of these had sickle- cell anaemia, and the third sickle-cell/haemoglobin-C disease. These three cases are the first examples of such a combination in adults we could find in the literature.