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Arginine (Arg) is an essential amino acid that can improve the reproductive capacity, intestinal development, and growth performance of pigs. N-carbamylglutamate (NCG) and N-acetylglutamate (NAG) can activate carbamyl phosphate synthetase I and the Δ1 pyrrolin 5 carboxylate synthetase in mitochondria, promoting the synthesis of citrulline from glutamine and proline, citrulline is the main precursors for the synthesis of Arg, and subsequently increasing the endogenous synthesis of Arg to produce nitric oxide (NO) and polyamines. Compared with Arg, NCG has a longer half-life and does not inhibit the absorption of basic amino acids such as histidine or lysine; thus, it has been developed as a feed additive. This paper reviews the application of NCG as a feed additive in pig production and its possible theoretical mechanism.
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Mao et al. (2026) studied this question.
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