The effect of environment on lactate dehydrogenase isozymes of cultured somatic cells

The lactate dehydrogenases of HeLa cells grown in an anaerobic environment with either glucose or L‐lactate have a higher ratio of A to B sub‐units than do the same cells grown in an aerobic environment. This ratio is decreased when the anaerobic environment is made aerobic during cell growth, or when the cells are cultured for the entire growth period in aerobic conditions.