April 1, 1982Journal of VirologyOpen Access

Linear mapping of tryptophan residues in Vesiculovirus M and N proteins by partial chemical cleavage

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Population

Matrix (M) and nucleocapsid (N) proteins of four members of the Vesiculovirus group

Design

Preclinical

Authors

Discussion

Supports viral protein mapping; extends conservation analysis across serotypes but leaves open functional and therapeutic implications.

Population

Matrix (M) and nucleocapsid (N) proteins of four members of the Vesiculovirus group

Intervention

Nonlimit chemical cleavage at tryptophan residues of protein labeled at the amino terminus

Outcome

Mapping of tryptophan positions

Demonstrates a simple procedure for mapping tryptophan positions and shows conservation of these residues in Vesiculovirus M and N proteins.

Brown et al. (1982) studied this question.

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