Key result
The time to reach the maximum temperature derivative during post-occlusion correlates with the maximum volumetric blood flow (r=0.6), demonstrating its utility in assessing hemodynamic response.
Why the study?
Does the time derivative of the temperature response to brachial occlusion correlate with hemodynamic parameters in healthy subjects?
Observational (n=60)
No
Does the time derivative of the temperature response to brachial occlusion correlate with hemodynamic parameters in healthy subjects?
Effect estimate: r=0.6
Using the first derivative of the temperature signal during a brachial occlusion test provides a quantitative measure of the hemodynamic response, which may aid in the noninvasive diagnosis of endothelial dysfunction.
Hypothesis-generating for noninvasive hemodynamic monitoring; leaves open validation for endothelial dysfunction assessment.
Objective. The aim of the study was to analyze the time derivative of temperature response of finger phalanges to brachial occlusion and to establish the relationship between the parameters of temperature dynamics and hemodynamic parameters. Materials and methods. To analyze the response to the occlusion, the methods of dynamic thermography and photoplethysmography (PPG) were used. The parameters of the temperature reaction on occlusion in a group of 60 healthy subjects were analyzed. The Shitzer model was used to establish the relationship between temperature dynamics and peripheral hemodynamics. Results. Parameters describing the temperature response of the fingers on occlusion were introduced. It is shown that the time to reach the maximum of the temperature derivative during post-occlusion corresponds to the maximum of the volumetric blood flow. A coefficient of symmetry is proposed that characterizes the curve of the hemodynamic response of the extremity vessels to a sharp restoration of blood flow after removal of the occlusion. The parameters of temperature dynamics paralleled to the changes in hemodynamic parameters. Conclusions. To compare the results of temperature measurements and results of optical methods of blood flow estimation it is advisable to use not the temperature signal but its first derivative. The use of temperature parameters, expressed in degrees, creates the conditions for the development of a quantitative approach to the description of the hemodynamic response to occlusion. The results of the study contribute to the development of noninvasive methods of diagnosing endothelial dysfunction as a harbinger of atherosclerosis.
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Сагайдачный et al. (2017) conducted an observational in Healthy (n=60). Brachial occlusion test vs. Baseline was evaluated on Correlation between time to maximum blood flow and time to maximum temperature derivative (r=0.6). The time to reach the maximum temperature derivative during post-occlusion correlates with the maximum volumetric blood flow (r=0.6), demonstrating its utility in assessing hemodynamic response.
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