An analysis of 617 Type 1 (insulin-dependent) diabetic patients from 587 families was made. In 33 families (5.6%) there was more than one Type 1 diabetic patient. In 98 families (16.7%) positive family history of Type 2 (non-insulin-dependent) diabetes was present. There was a linear correlation between the age at diagnosis of the proband and that of the sibling (r = 0.73, p less than 0.001) in the Type 1 multiplex families. The risk of Type 1 diabetes in relatives was found to be 2.7% by Li Mantel estimate, which is lower than that reported among Europeans. The cumulative risk was higher (p less than 0.001) in the relatives of Type 1 diabetic patients with age at diagnosis less than or equal to 10 years.
No takes yet. Share an insight, caveat, or question.
Ramachandran et al. (1990) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: