Adult BALB/c female mice raised in the laboratory colony possess spleen cells capable of significant cytotoxic activity against target mammary tumor virus-(MTV) induced mammary tumor cells. If BALB/c females are raised in isolation, their spleen cells are not reactive. Reactivity can be induced in isolated females by caging them with a mouse neonatally infected with MTV. These data provide immunologic evidence for the horizontal transmission of MTV.
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Blair et al. (1974) studied this question.