Key result
Skeletal muscle myosin directly enhances prothrombin activation by binding factors Xa and Va (p=0.0004), potentially augmenting thrombosis risk in the setting of acute injuries.
Why the study?
Does skeletal muscle myosin enhance prothrombin activation?
Does skeletal muscle myosin enhance prothrombin activation?
Skeletal muscle myosin directly enhances prothrombin activation, which may promote hemostasis or augment thrombosis risk in the setting of acute injuries.
May heighten post-injury thrombosis vigilance; leaves open clinical relevance of myosin-prothrombin binding.
= .0004), implying myosin might contribute to acute trauma coagulopathy. We posit that myosin enhancement of thrombin generation could contribute either to promote hemostasis or to augment thrombosis risk with consequent implications for myosin's possible contributions to pathophysiology in the setting of acute injuries.
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Deguchi et al. (2016) studied this question. Skeletal muscle myosin directly enhances prothrombin activation by binding factors Xa and Va (p=0.0004), potentially augmenting thrombosis risk in the setting of acute injuries.
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