The development of tolerance to the beneficial effects ofinhaled P2 agonists has been suggested as one possible explanation for the deleterious effects of frequent use of these agents in asthma.' The two main beneficial phar- macological effects of inhaled 12 agonists in asthma are bronchodilation and functional ant- agonism.2 Although it has been difficult to show appreciable tolerance to the bronchodilator efficacy of these agents,3 regular use of inhaled 12 agonists predictably causes tolerance to the functional antagonist (bronchoprotective effect) of these drugs.' In this review we will discuss the topic of tolerance to the broncho- protective effect of inhaled 12 agonist and its potential clinical relevance.
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Cockcroft et al. (1996) studied this question.
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