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An I‐active substance was isolated from the aqueous layer obtained after extraction of human erythrocyte membranes with n‐butanol. This substance was found to be identical with the antigens with A, B, and H blood group specificity which we had isolated previously. Thus, all A, B, H and I blood group activity in aqueous extracts of erythrocyte membranes is dependent upon the same kind of antigenic material which may carry different blood group specificities. The material is sialic acid free and comprises about 90% carbohydrate.
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Gardas et al. (1974) studied this question.
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