Key result
High serum ferritin (highest vs lowest quartile) was independently associated with high arterial stiffness in healthy Korean men (OR 1.46; 95% CI 1.29-2.17) and women (OR 1.80; 95% CI 1.25-2.82).
Why the study?
Is higher serum ferritin associated with increased arterial stiffness in healthy adults?
Cross-Sectional (n=2,932)
Is higher serum ferritin associated with increased arterial stiffness in healthy adults?
Higher serum ferritin levels are independently associated with increased arterial stiffness in healthy Korean adults.
Answers are grounded in this paper and cite their sources.
Should not yet change practice; hypothesis-generating for ferritin-arterial stiffness links requiring prospective confirmation.
Although an association between serum ferritin and atherosclerosis has been suggested, limited epidemiologic data are available regarding the association between ferritin and arterial stiffness in healthy adults. A total of 2932 healthy subjects were enrolled in this study. Anthropometric and biochemical profiles including ferritin were measured. The arterial stiffness was measured using brachial-ankle pulse wave velocity (baPWV). Serum ferritin levels were classified into quartiles and baPWV values gradually increased with each ferritin quartile. Multiple regression analysis showed that ferritin levels were independently correlated with baPWV. After adjusting for multiple risk factors, as compared with the lowest quartile, the odds ratios for high baPWV (>75(th) percentile) were 1.15 (0.84-1.56), 1.37 (0.97-1.73), and 1.46 (1.29-2.17) among men (p for trend < 0.05) and 1.24 (0.87-1.79), 1.53 (1.09-2.16), and 1.80 (1.25-2.82) among women (p for trend < 0.05), for the second, third, and fourth quartiles of ferritin, respectively. In conclusion, serum ferritin levels are independently associated with arterial stiffness in healthy Korean adults.
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Ha et al. (2016) conducted a cross-sectional in Healthy adults (n=2,932). High serum ferritin levels vs. Lowest quartile of serum ferritin was evaluated on High brachial-ankle pulse wave velocity (>75th percentile) (OR 1.46, 95% CI 1.29-2.17, p=<0.05). High serum ferritin (highest vs lowest quartile) was independently associated with high arterial stiffness in healthy Korean men (OR 1.46; 95% CI 1.29-2.17) and women (OR 1.80; 95% CI 1.25-2.82).
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