Non-Antibiotic-Associated Pseudomembranous Colitis Due to Toxin-Producing Clostridia

Brief Reports1 June 1980Non-Antibiotic-Associated Pseudomembranous Colitis Due to Toxin-Producing ClostridiaARNOLD WALD, M.D., HARVEY MENDELOW, M.D., JOHN G. BARTLETT, M.D.ARNOLD WALD, M.D.Search for more papers by this author, HARVEY MENDELOW, M.D.Search for more papers by this author, JOHN G. BARTLETT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-6-798 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn recent years pseudomembranous colitis has most often been described in a setting of antibiotic therapy. Recent studies have implicated toxin-producing clostridia organisms in the intestine in the pathogenesis of antibiotic-associated pseudomembranous colitis (1-3). Clinical disease has been reported to occur as late as three weeks after discontinuing antibiotic therapy (4). To our knowledge, all but one of the reported cases of pseudomembranous colitis in which the clostridia toxin has been found in fecal extracts have occurred in the setting of antibiotic therapy. This report describes a previously healthy woman who was found to have pseudomembranous colitis without known exposure...References1. BARTLETTCHANGGURWITHGORBACHONDERDONK JTMSA. Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia. N Engl J Med. 1978;298:531-4. CrossrefMedlineGoogle Scholar2. RIFKINSILVAFEKETY GJR. Gastrointestinal and systemic toxicity of fecal extracts from hamsters with clindamycin-induced colitis. Gastroenterology. 1978;74:52-7. CrossrefMedlineGoogle Scholar3. LARSONPRICE HA. Pseudomembranous colitis: presence of clostridial toxin. Lancet. 1977;2:1312-4. CrossrefMedlineGoogle Scholar4. TEDESCOBARTONALPERS FRD. Clindamycin-associated colitis: a prospective study. Ann Intern Med. 1974;81:429-33. LinkGoogle Scholar5. PRICEDAVIES AD. Pseudomembranous colitis. J Clin Pathol. 1977;30:1-12. CrossrefMedlineGoogle Scholar6. ASWELLEHRICHVANTASSELLTSAIHOLDEMANWILKINS JMRCLT. Characterization and comparison of Clostridium difficile and other clostridial toxins. In: SCHLESSINGER D, ed. Microbiology—1979. Washington, D.C.: American Society for Microbiology; 1979:272-5. Google Scholar7. GOULSTONMCGOVERN SV. Pseudo-membranous colitis. Gut. 1965;6:207-12. CrossrefMedlineGoogle Scholar8. TEDESCOGURWITHMARKHAMCHRISTIEBARTLETT FMRDJ. Oral vancomycin for antibiotic-associated pseudomembranous colitis. Lancet. 1978;2.226-8. CrossrefMedlineGoogle Scholar9. KEIGHLEYBURDONARABI MDY. Randomised controlled trial of vancomycin for pseudomembranous colitis and postoperative diarrhoea. Br Med J 1978;2:1667-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByInflammatory Disorders of the Large IntestineMicroorganisms Responsible for Neonatal DiarrheaDIARRHOEA AND ACUTE SPECIFIC COLITISMicroorganisms Responsible for Neonatal DiarrheaClostridium difficile colitis unassociated with antibiotic therapyCommunity-Acquired, Non-Antibiotic-Associated Clostridium difficile Colitis in a ChildPseudomembranous GastritisEntzündliche Erkrankungen des Dickdarms, Anorektums und PerianalbereichsPSEUDOMEMBRANOUS PANENTERITIS AND SEPTICAEMIA IN A PATIENT WITH ULCERATIVE COLITISEntzündliche Erkrankungen des Dickdarms, Anorektums und PerianalbereichesCLOSTRIDIUM DIFFICILE INFECTION IN HEALTH-CARE WORKERSClinical and pathological variability of infection by enterohaemorrhagic (Vero cytotoxin producing) Escherichia coli.Antimicrobial Agent–Associated Diarrhea in Adult HumansClostridium difficile: its disease and toxinsPathology of inflammatory bowel disease in colorectal mucosal biopsiesClostridium difficile in general practice and community healthEntzündliche Erkrankungen des Dickdarms, Anorektums und PerianalbereichesInfektiöse KrankheitsbilderA Comparison of the Clinico-pathological Features with Stool Pathogens in Patients Hospitalised with the Symptom of DiarrhoeaDiagnosis of Clostridium Difficile-Associated Intestinal DiseaseRoutine culturing for clostridium difficile?Nosocomial Spread of Clostridium DifficileDiarrhoea associated with Clostridium difficile in a hospital populationPseudomembranöse ColitisPseudomembranous ColitisMucosal biopsy of the rectum, colon, and distal ileumPossible Foodborne Transmission in a Case of Pseudomembranous Colitis Due to Clostridium difficileMedical Management of Antimicrobial-Associated Diarrhea and ColitisIs Clostridium difficile pathogenic in infants?Clostridium difficile toxin in asymptomatic neonatesClostridium difficile in association with sporadic diarrhoea.Nonantibiotic-associated enterocolitis caused by Clostridium difficile in an infantSurvival after necrotizing enterocolitis of leukemia treated with oral vancomycinAssociation of Clostridium difficile toxin with symptomatic relapse of chronic inflammatory bowel diseaseOccurrence of Clostridium difficile toxin during the course of inflammatory bowel diseaseRapid detection of Clostridium difficile toxin in human fecesTransmissible Agents in Inflammatory Bowel Disease: 1980Clostridial Pseudomembranous ColitisNARUMI OHARA, B.A., RICHARD F. GAEKE, M.D., DAVID CAVE, M.D., PH.D., JOSEPH B. KIRSNER, M.D., PH.D. 1 June 1980Volume 92, Issue 6Page: 798-799KeywordsAntibioticsC difficile colitisPathogenesisToxins Issue Published: 1 June 1980 PDF DownloadLoading ...