A modified method of Roberts & Quastel has been used to study the influence of temperature, metabolic inhibitors and EDTA on human leucocyte phagocytosis. The phagocytosis was increased by raising the temperature from 4° to 37° C. 2-deoxy-D-glucose inhibited phagocytosis. Antimycin or oligomycin had no influence. The greatest inhibition of phagocytosis was obtained by a combination of 2-deoxy-D-glucose and antimycin or oligomycin, demonstrating that the energy may derive from both glycolysis and respiration, the main source being glycolytic energy. Increasing concentrations of EDTA from 2 to 4 mM as final concentrations decreased phagocytosis.
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Bernt Kvarstein (1969) studied this question.
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