Key result
Oral administration of 50 mg/kg of the chloroform fraction of Euphorbia maculata significantly reduced ADP-induced platelet aggregation in rats to 51.25% compared to 71.73% in untreated controls.
Why the study?
Does the chloroform fraction of Euphorbia maculata reduce platelet aggregation in rats?
Does the chloroform fraction of Euphorbia maculata reduce platelet aggregation in rats?
Absolute Event Rate: 51.25% vs 71.73%
p-value: p=<0.05
The chloroform fraction of Euphorbia maculata demonstrates antiplatelet activity through the suppression of TXB2 formation without increasing bleeding risk in a rat model.
Hypothesis-generating for plant-derived antiplatelet agents; leaves open human translation and safety trials.
Euphorbia maculata (EM) is a traditionally used antidiarrheal, antibacterial, antifungal and antioxidant agent. However, the effects of EM on platelet activity remain to be elucidated. Therefore, the present study investigated the antiplatelet effect of various EM extract fractions on platelet aggregation in rats. The antiplatelet activity of the EM fractions on collagen or adenosine diphosphate (ADP)‑induced platelet aggregation was evaluated in vitro and ex vivo. Thromboxane B2 (TXB2) formation, rat‑tail bleeding time and coagulation time were also measured. Among the fractions, the chloroform fraction of EM (CFEM) significantly inhibited ADP‑induced platelet aggregation in vitro. Furthermore, oral administration of 50 mg/kg CFEM to rats significantly reduced ADP‑induced platelet aggregation without increasing the tail bleeding time or coagulation time. In addition, EM significantly inhibited the level of TXB2 formation in a dose‑dependent manner. These results suggest that CFEM exhibits antiplatelet activity, without causing bleeding, via the suppression of TXB2 formation. CFEM may be a type of food which has the potential for preventing cardiovascular disease.
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Kwon et al. (2015) studied Platelet aggregation (n=30). Chloroform fraction of Euphorbia maculata (CFEM) vs. Water (untreated control) was evaluated on ADP-induced platelet aggregation rate (p=<0.05). Oral administration of 50 mg/kg of the chloroform fraction of Euphorbia maculata significantly reduced ADP-induced platelet aggregation in rats to 51.25% compared to 71.73% in untreated controls.
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