Novel Raman tags with various reporter molecules embedded in between gold nanostar (AuNS) and gold nanoshell are developed, showing significantly enhanced surface-enhanced Raman scattering intensity compared to gold nanoparticle-based composites. Immunoassay using these AuNS@tag@shell structures is highly specific with sensitivity down to 0.1 pg mL−1, and is capable of multiplex detection, making them highly promising for biosensing applications.
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Yang et al. (2016) studied this question.
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