Key result
Balanced salt solutions such as Plasmalyte and Ringer's lactate resulted in a significantly higher pH at the end of surgery compared to normal saline (7.31 and 7.33 vs 7.29), though this did not affect early postoperative graft function.
Why the study?
The optimal perioperative crystalloid in renal transplant surgeries remains debated, as normal saline may cause hyperchloremic acidosis while balanced salt solutions may cause hyperkalemia.
Do balanced salt solutions improve acid-base balance and graft function compared to normal saline in patients undergoing living donor kidney transplantation?
RCT (n=180)
Double-blind
Computer-based block randomization
No
Do balanced salt solutions improve acid-base balance and graft function compared to normal saline in patients undergoing living donor kidney transplantation?
Balanced salt solutions maintain better intraoperative acid-base and electrolyte balance compared to normal saline during renal transplant surgery, though without significant impact on early graft function.
Answers are grounded in this paper and cite their sources.
Balanced crystalloids improve acid-base balance without affecting graft function; leaves open clinical relevance in larger or deceased-donor trials.
Background The importance of optimal acid-base balance during renal transplant surgeries cannot be stressed enough. Optimal preload and electrolyte balance is important in maintaining this. There has been a debate on the choice of perioperative crystalloids in renal transplant surgeries over the past decades. Normal saline (0.9% saline) is more likely to cause hyperchloremic acidosis when compared to balanced salt solutions (BSS) with low chloride content whereas BSS may cause hyperkalemia. We aim to compare the safety and efficacy of normal saline (NS), Ringer's lactate (RL) and Plasmalyte (PL) on acid-base balance and electrolytes during living donor kidney transplantation. Materials and methods Patients were randomized to NS group (n = 60), RL group (n = 60) and Plasmalyte group (n = 60). Arterial blood samples were collected for acid-base analysis after induction of anaesthesia (T0), prior to clamping the iliac vein (T1), 10 minutes after reperfusion of the donated kidney (T2) and at the end of surgery (T3). In addition, serum creatinine and 24-hour urine output were recorded on postoperative days one, two and seven. Results There was a statistically significant difference (p < 0.001) in the pH at the end of surgery between the three groups with the NS group being more acidotic (pH 7.29 ± 0.06, 95% CI 7.27-7.32), although this was not clinically relevant. This was explainable by the parallel increase in chloride in the NS group. Early postoperative graft functions in terms of serum creatinine, urine output and graft failure requiring dialysis were not significantly different between the groups. Conclusion Balanced salt solutions such as Plasmalyte and Ringer's lactate are associated with better pH and chloride levels compared to normal saline when used intraoperatively in renal transplant patients. This difference, however, does not appear to have any bearing on graft function. Plasmalyte seems to maintain a better acid-base and electrolyte balance, especially during the postreperfusion period.
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Saini et al. (2021) conducted an RCT in Living donor kidney transplantation (n=180). Balanced crystalloids (Plasmalyte or Ringer's lactate) vs. 0.9% Normal saline was evaluated on pH at the end of surgery (MD -0.02, p=0.024). Balanced salt solutions such as Plasmalyte and Ringer's lactate resulted in a significantly higher pH at the end of surgery compared to normal saline (7.31 and 7.33 vs 7.29), though this did not affect early postoperative graft function.
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