A simple colorimetric method for the determination of six nitro derivatives, namely: furazolidone, nifuroxime, niridazole, nitrazepam, nitrofurantoin and nitrofurazone was described. The suggested method depends upon the formation of orange to purple colour when these nitro compounds react with tetrabutylammonium hydroxide in dimethylformamide. The different experimental parameters were studied and incorporated into the procedure. The mean percentage recoveries ranged from 98.9 ± 0.3 to 100.4 ± 0.7. The proposed method was applied to the determination of certain pharmaceutical dosage forms containing the studied nitro-compounds, as well as furazolidone and nifuroxime in mixture. The results obtained were in agreement with those obtained by official and compendium methods.
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Walash et al. (1993) studied this question.
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