The distribution volume and the total clearance of inulin and [51Cr]EDTA (etylene-diamine-tetraacetic-acid labelled with 51Cr) was compared using a single injection technique without urine sampling in 22 measurements in patients. The distribution volume of [51Cr]EDTA exceeded the distribution volume of inulin by 75 per cent, while the total clearances were not significantly different. In five nephrectomized dogs the [51Cr]EDTA distribution volume was 90 per cent higher than inulin distribution volume, while the extrarenal clearance was not significantly different.
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Ladegaard‐Pedersen et al. (1972) studied this question.
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