A technic is described which makes possible the precise localization of left-to-right intra- or extracardiac shunts and the detection of aortic and mitral valvular insufficiency. An indicator dye is rapidly injected into chambers of the left heart or aorta and a dilution curve is recorded from a peripheral artery. The method has been applied in 33 patients and has proven of diagnostic value.
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Braunwald et al. (1957) studied this question.