Highly Enantioselective One-Pot Synthesis of Chiral Tri- and Tetrasubstituted Ferrocenes from 1,1′-Ferrocenedicarbaldehyde

Exclusively planar chirality is exhibited by the ferrocenes obtained in a highly enantioselective synthesis in which a chiral aminoamide acts as a temporary protecting/directing group. This method was used to obtain an enantiomerically pure tetrasubstituted ferrocene, which was transformed into the first C2-symmetric disubstituted ferrocenophane [Eq. (1)].