The photochemical cyclisation of 11‐keto steroids to 11β, 19‐cyclo‐11‐hydroxy compounds is strongly influenced by steric factors. The presence of a gem‐dimethyl group at C‐4 gives rise to a marked improvement in the yield of the cyclic product. The nature of this steric interaction is briefly discussed.
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Iriarte et al. (1963) studied this question.
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