Key result
R-CHOP therapy in a patient with follicular lymphoma was associated with an elevation in cardio-ankle vascular index and new carotid plaque formation, indicating potential progression of arteriosclerosis.
Why the study?
Does R-CHOP therapy increase arterial stiffness and plaque formation in a patient with follicular lymphoma?
Case Report (n=1)
No
Does R-CHOP therapy increase arterial stiffness and plaque formation in a patient with follicular lymphoma?
R-CHOP therapy may accelerate arteriosclerosis, highlighting the potential need for vascular monitoring in cancer survivors undergoing this chemotherapy.
Hypothesis-generating for R-CHOP vascular effects in lymphoma; leaves open need for prospective monitoring studies.
An increased risk of arteriosclerosis has been noted in cancer survivors. Currently, there are only a few reports available that consider the risk of arteriosclerosis in patients treated with chemotherapy. Patients with an advanced stage B-cell malignant lymphoma are typically treated with a combination therapy of rituximab and cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP). Complications such as diabetes mellitus (DM), hyperlipidemia (HL), and osteoporosis due to prednisolone and cardiotoxicity due to anthracyclines are well known. However, there are no studies that have investigated the link between R-CHOP therapy and arteriosclerosis. We discussed a patient with follicular lymphoma who was evaluated using cardio-ankle vascular index (CAVI) as an arterial stiffness parameter during R-CHOP therapy in this report. She achived complete remission after the eighth course therapy without complications such as hypertension (HT), HL, DM, and infection. This patient showed elevated CAVI with new plaque formation in the carotid arteries after the end of chemotherapy. These data indicate that R-CHOP therapy may progress the arteriosclerosis.
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Shimizu et al. (2017) conducted a case report in Follicular lymphoma (n=1). R-CHOP therapy vs. Pre-treatment baseline was evaluated on Cardio-ankle vascular index (CAVI). R-CHOP therapy in a patient with follicular lymphoma was associated with an elevation in cardio-ankle vascular index and new carotid plaque formation, indicating potential progression of arteriosclerosis.
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