Key result
The kidney-heart macrophage axis plays a key role in the development of cardiorenal syndrome after myocardial infarction by promoting cardiac macrophage polarization, myocardial hypertrophy, and fibrosis.
Why the study?
Cardiorenal syndrome in acute myocardial infarction drives heart and renal failure, and the kidney-heart macrophage axis may represent a key cellular mechanism alongside renin-angiotensin activation.
The kidney-heart macrophage axis is proposed as a key cellular mechanism underlying cardiorenal syndrome in patients with myocardial infarction.
Hypothesis-generating for kidney-heart macrophage axis in post-MI CRS; prospective validation required before clinical consideration.
Cardiorenal syndrome (CRS) in patients with acute myocardial infarction (MI) underlies the development and progression of renal and heart failure. Along with the well-known mechanisms of CRS development based on reninangiotensin system activation, kidney-heart macrophage axis may be one of the key cellular components of CRS. Continuous sympathetic stimulation of collecting duct system cells under ischemia activates the macrophage link of the kidneys, which contributes to cardiac macrophages' polarization and leads to the development of adaptive myocardial hypertrophy and fibrosis. This review article summarizes current data on interaction of macrophages in the kidney-heart axis, which can be considered as the cellular basis for CRS development in patients with MI. The translation of experimental data on the participation of innate immune system on CRS model in humans will make it possible to find new ways to prevent and suppress acute kidney injury in patients with MI.
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Керчева et al. (2021) conducted a review in Myocardial infarction and cardiorenal syndrome. Macrophage interaction in the kidney-heart axis was evaluated. The kidney-heart macrophage axis plays a key role in the development of cardiorenal syndrome after myocardial infarction by promoting cardiac macrophage polarization, myocardial hypertrophy, and fibrosis.
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