Chemical synthesis study demonstrates photoinduced reductive borylation of inert alkyl heteroaryl ethers, enabling late-stage functionalization of complex natural and medicinal compounds.
A photoinduced reductive C alkyl –O borylation of alkyl heteroaryl ethers with very negative reduction potential in the presence of 4-dimethylaminopyridine (DMAP) and bis(catecholato)diborane(B 2 cat 2 ) was developed. Despite the high reducing power, various substrates with liable functional groups were well-tolerated as well as ethers derived from natural products and medicinal-relevant compounds. Mechanistic investigation implied that an intra-single electron transfer process in an electron donor–acceptor complex formed from ethers with the adduct of B 2 cat 2 and DMAP should be involved.
No takes yet. Share an insight, caveat, or question.
Wang et al. (2023) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: