Answers are grounded in this paper and cite their sources.
Calcium ions regulate almost all cellular processes. Inositol 1,4,5‐trisphosphate receptors (IP3Rs) are ubiquitous calcium channels which mediate calcium release primarily from endoplasmic reticulum stores. IP3Rs are activated by the soluble second messenger inositol 1,4,5‐trisphosphate (IP3), which is produced in response to various stimuli by the action of phospholipase C enzymes. Very soon after the discovery that IP3 is a calcium mobilizing second messenger, it was found that T‐cell receptor signaling is dependent upon IP3R activity. It is now known that cell signaling throughout the immune system is dependent upon IP3R‐dependent calcium release for many critical processes, including cellular activation, proliferation, and death. This channel plays a critical role in orchestrating the immune response in health and disease and thus offers potential as a therapeutic target in immune‐related disorders. WIREs Membr Transp Signal 2012,1:329–339. doi: 10.1002/wmts.27 For further resources related to this article, please visit the WIREs website .
No takes yet. Share an insight, caveat, or question.
Akimzhanov et al. (2011) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: