Why the study?
Are renin gene polymorphisms associated with aldosterone responsiveness to the renin-angiotensin system in patients with aldosterone-producing adenomas?
Are renin gene polymorphisms associated with aldosterone responsiveness to the renin-angiotensin system in patients with aldosterone-producing adenomas?
Allelic variation in the constitutive renin gene is associated with aldosterone responsiveness in patients with aldosterone-producing adenomas, representing a specific genetic link to a cause of secondary hypertension.
Should not yet change practice in adenoma management; leaves open a genetic link requiring prospective validation.
Aldosterone levels in patients with unilateral aldosterone-producing adenomas may be responsive or unresponsive to the renin-angiotensin system, with the former often previously misdiagnosed as bilateral adrenal hyperplasia. 2. In tumours from patients in the responsive subgroup, renin mRNA is expressed in greater amounts than in tumours from patients in the unresponsive subgroup, or in normal adrenals. 3. We compared the frequency of four renin gene polymorphisms in peripheral blood DNA from the two subgroups and found significant associations between BglI, TaqI and HinfI restriction fragment length polymorphisms (RFLP) and aldosterone responsiveness. 4. Allelic variation in the constitutive renin gene was associated with a specific cause of hypertension.
No takes yet. Share an insight, caveat, or question.
Ballantine et al. (1994) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: